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For the microcephalin gene, the variation arose about 37,000 years ago, about the time period when art, music and tool-making were emerging, Lahn said.For ASPM, the variation arose about 5,800 years ago, roughly correlating with the development of written language, spread of agriculture and development of cities, he said.Years later, a ruler declares one of those copies the definitive manuscript, and a rush is on to make many copies of that version — so whatever changes from the original are in this presumed important copy become widely disseminated.Scientists attempt to date genetic changes by tracing back to such spread, using a statistical model that assumes genes have a certain mutation rate over time.Those criticisms are particularly important, Collins said, because Lahn's testing did find geographic differences in populations harboring the gene variants today.They were less common in sub-Saharan African populations, for example.The work was funded by the Howard Hughes Medical Institute. A family tree of Indo-European languages suggests they began to spread and split about 9,000 years ago.

The resulting tree matches many existing ideas about language development.That the genetic changes have anything to do with brain size or intelligence "is totally unproven and potentially dangerous territory to get into with such sketchy data," stressed Dr.Francis Collins, director of the National Human Genome Research Institute."A different way to look at is it's almost impossible for evolution not to happen." Still, the findings also are controversial, because it's far from clear what effect the genetic changes had or if they arose when Lahn's "molecular clock" suggests — at roughly the same time period as some cultural achievements, including written language and the development of cities.Lahn and colleagues examined two genes, named microcephalin and ASPM, that are connected to brain size.

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